PATHOGENESIS OF ATHEROSCLEROSIS AND ALPHA LIPOIC ACID AS A POTENTIAL THERAPEUTIC AGENT AGAINST ATHEROSCLEROSIS - A REVIEW

Received 2020-03-12; Accepted 2020-06-16; Published 2020-09-04

Authors

  • Vivi Noryati Ahmad Centre of Preclinical Science Studies, Faculty of Dentistry, Universiti Teknologi MARA, Sg. Buloh, Selangor Darul Ehsan, Malaysia.
  • Zulkhairi Amom Centre of Preclinical Science Studies, Faculty of Dentistry, Universiti Teknologi MARA, Sg. Buloh, Selangor Darul Ehsan, Malaysia.
  • Indah Mohd Amin Centre of Preclinical Science Studies, Faculty of Dentistry, Universiti Teknologi MARA, Sg. Buloh, Selangor Darul Ehsan, Malaysia.
  • Nur Batrisyia Ruslan Centre of Preclinical Science Studies, Faculty of Dentistry, Universiti Teknologi MARA, Sg. Buloh, Selangor Darul Ehsan, Malaysia.
  • Nurhayati Mohamad Zain Centre of Preclinical Science Studies, Faculty of Dentistry, Universiti Teknologi MARA, Sg. Buloh, Selangor Darul Ehsan, Malaysia.
  • Mohd Aizat Abdul Rahim Centre of Preclinical Science Studies, Faculty of Dentistry, Universiti Teknologi MARA, Sg. Buloh, Selangor Darul Ehsan, Malaysia.

DOI:

https://doi.org/10.22452/jummec.vol23no2.7

Keywords:

Atherosclerosis, Cholesterol, Oxidative Stress, Inflammation, Antioxidant, Alpha Lipoic Acid

Abstract

Studies have found the association between hypercholesterolemia with oxidative stress and atherogenesis. Atherosclerosis has become one of the leading causes of mortality among industrial countries due to abnormal cholesterol metabolism, inflammation of arterial wall and build-up of atherosclerotic plaque. This disease has been recently linked with alpha lipoic acid (ALA), a mitochondrial compound with antioxidative effects in water- and fat-soluble mediums, in both oxidized and reduced forms: lipoic acid (LA) and dihydrolipoic acid (DHLA), respectively. This article provides a comprehensive review of the development and progression of atherosclerosis and the roles and regulations of ALA as a potent antioxidant against atherosclerosis.

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Published

2020-09-04

Issue

Vol. 23 No. 2 (2020)

Section

Research article

License

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