HEART FAILURE WITH PRESERVED EJECTION FRACTION AND OBESITY: A REVIEW: Received 2022-01-15; Accepted 2022-10-01; Published 2022-12-31

Nur Alya Syamimie Muzaidi; Teoh Soo Huat; Mastura Mohd Sopian

doi:10.22452/jummec.sp2022no1.17

HEART FAILURE WITH PRESERVED EJECTION FRACTION AND OBESITY: A REVIEW

Received 2022-01-15; Accepted 2022-10-01; Published 2022-12-31

Authors

Nur Alya Syamimie Muzaidi Department of Clinical Medicine, Institut Perubatan & Pergigian Termaju, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, Malaysia
Teoh Soo Huat Department of Clinical Medicine, Institut Perubatan & Pergigian Termaju, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, Malaysia
Mastura Mohd Sopian Department of Clinical Medicine, Institut Perubatan & Pergigian Termaju, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, Malaysia

DOI:

https://doi.org/10.22452/jummec.sp2022no1.17

Abstract

Heart Failure with Preserved Ejection Fraction (HFpEF) is becoming more common as the United States (U.S.A) population ages, along with the present of obesity pandemic. In general, HFpEF is the most common type of heart failure (HF) found in general population, however, the elderly, especially women are mostly suffering from it. It is primarily caused by obesity, hypertension, coronary artery disease, and diabetes. Obesity is frequent in individuals with HFpEF. However, it may constitute a distinct phenotype of HFpEF, with distinct hemodynamic and anatomical problems. Obesity causes a systemic inflammatory response which can lead to cardiac fibrosis and endothelial dysfunction. Because most obese patients are still excluded from HFpEF clinical trials, further research is needed to evaluate the role of pharmacologic and interventional treatments in this expanding group. Thus, this review study will aid in the understanding of HFpEF and its association with obesity.

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Globally, the prevalence of both communicable and non-communicable diseases has reached pandemic levels. The prevalence of diseases including type 2 diabetes, hypertension, and obesity is worldwide. With the help of technology, many of the most severe infectious diseases of the 20th century may now be fought. These disorders are conditions that develop over an extended period of time as a result of a combination of genetic, physiological, environmental, and behavioural factors, especially the non-communicable diseases. The goal of this Special Issue, "Combating disease: Current trends, risk, treatment and prevention" is to discuss a wide range of disease-related topics, including make studies about the current pandemic season public. We specially encourage articles that offer fresh perspectives on medicine, medical systems, and management including epidemiological studies, basic science of local and systemic responses related to the medical sciences, fundamental research in medical sciences in lowering risk, improving treatment and prevention. All Special issues of JUMMEC follow the exact peer review process as regular papers and are published along with the regular issues of the journal when they are accepted. There are additionally labelled as belonging to a Special Issue and share a particular topic of interest to the scientific community.

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Published

2022-12-31

Issue

Special Issue 1 (2022) Combating disease: Current trends, risk, treatment and prevention

Section

Research article

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