ROLE OF LACTOFERRIN ON THE HISTOPATHOLOGICAL CHANGES OF HYPERLIPIDEMIC-INDUCED FATTY LIVER IN RATS

Received 2023-01-01; Accepted 2023-05-15; Published 2023-08-18

Authors

  • Valencia Chandra School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta Indonesia.
  • Louis Fabio Jonathan Jusni School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta Indonesia.
  • Tena Djuartina Department of Anatomy, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta Indonesia.
  • Dion Notario Department of Pharmacy, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta Indonesia.
  • Zita Arieselia Department of Pharmacology, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta Indonesia.
  • Linawati Hananta Department of Pharmacology, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta Indonesia.

DOI:

https://doi.org/10.22452/jummec.vol26no2.22

Abstract

Introduction: Hyperlipidemia is a condition that may lead to many illnesses. The worldwide prevalence of hyperlipidemia is still relatively high. Lactoferrin is a glycoprotein found in mammals and fishes’ epithelial mucosa cells, also known for its protective roles.

Objective: This study aims to discover the histopathologic changes in rat’s liver after the intervention of 100, 200, and 400 mg/kgBW lactoferrin.

Method: This study involved 30 Sprague-Dawley rats divided into six groups: normal, negative control, statin-treated, dose 1, dose 2, and dose 3. The normal group was given standard feed, while the other groups were hyperlipidemic induced by a high cholesterol diet. The intervention for the statin-treated group was 1.5 mg/kgBW statin, while dose 1, 2, and 3 were respectively given 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW of lactoferrin. After six weeks, all rats were dissected, and the livers’ histopathologic slides were scored with Manja Roenigk scoring.

Result: Lactoferrin improved the fatty liver condition. The statistical test results showed that 200 mg/kgBW of lactoferrin caused a significant change in the rats’ liver structures (p < 0.05).

Conclusion: 200 mg/kgBW of lactoferrin significantly improved the histopathologic structure of fatty liver

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Published

2023-08-18

Issue

Vol. 26 No. 2 (2023)

Section

Research article

License

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